This paper seeks to shed some light on the possible geopolitical consequences of Coronavirus at the international level, mainly regarding the US-China rivalry, on the EU future and on its relations with its “Mediterranean and Arab neighbours, and on the MENA region, as a whole. The research questions are the following: will this global health disease exacerbate US-China competition or will it usher in more cooperation? Will it put the EU project at risk or will the EU transform this crisis into a new opportunity for a stronger and safer Europe? Will this crisis lead to another AMENA’s (Arab Middle East and North Africa) future freer, more integrated, more prosperous or to the consolidation of the current stalemate or even to failed states? And, finally, will this crisis reinforce the current apathy in the EU-Arab relations or will it force the EU to assess critically and rethink its relations with its neighbours, overhaul its old-fashioned policies, and inject new life in its global outreach?