Defining the Mediterranean as a ‘region’ suggests a deeper and more profound reading of such definition, which has several implications. First of all, it is necessary to identify how terms such as ‘region’ and ‘regionalism’ can be defined and how these concepts are consistent with the geo-political area of the Mediterranean. An area that has always captured great interests not only among scholars of geography but also of international studies (IR) and humanitarian disciplines (sociologists, linguistics, historians, etc.) (Schäfer, 2014), whose vision encompasses that of a succession of a multitude of cultures towards and within it; where the (co)occurrence of various phenomena have manifested throughout the years. Mediterranean Studies represents a necessary instrument de facto to provide a comprehensive vision of the region as such. However, having tried to provide an effective definition of the Mediterranean region, the next step will be necessarily to reflect on the EU-Mediterranean relationships in order to further discover the interactions between diverse actors and events. The interest shown towards the Mediterranean region is due to the desire to better comprehend and mentally recreate a sort of mapping that highlights where the Mediterranean region begins and ends, or in other words which are its borders. As a matter of fact, the main features of the Mediterranean will emerge spontaneously, stressing how relevant and crucial the role of diversity is.